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Synovial sarcoma is one of the rarest types of cancer. This type of soft tissue sarcoma can arise almost anywhere in the body, including the joints.

Synovial sarcoma most commonly occurs in the extremities, particularly in the thighs, knees, feet and forearms.

However, it also can occur in the head, neck and trunk. We spoke with Dejka M. Araujo, M. Yeagley to learn more about diagnosis, treatment options and the latest research on synovial sarcoma.

What are common synovial sarcoma symptoms? At what point should someone see a doctor? Most synovial sarcoma patients discover their tumor from a lump, and for some, related pain.

Synovial sarcoma may also occur in the lungs, so see your doctor if you notice shortness of breath. There are two major types: monophasic, which is made up of only spindle cells, and biphasic, which is made up of both spindle cells and epithelial cells.

We also see it in men slightly more often than women. However, an official diagnosis can only be made by a pathologist after obtaining tissue samples through biopsy or surgery.

Do your research. If possible, see a doctor who specializes in sarcoma and works at a cancer center that has surgeons, radiation oncologists and pathologists who also specialize in sarcoma.

If the diagnosis was made after the tumor was removed, make sure the doctors got all the cancer out. At present, surgery is the most effective treatment, but radiation and chemotherapy may extend the time before recurrence and metastasis when used in conjunction with surgery.

Yes, synovial sarcoma often does spread to other parts of the body. The lungs are the most common, and usually the first, site of metastasis for synovial sarcoma.

Metastasis to the brain, bone, lymph nodes and local organs are all possibilities. MD Anderson has two clinical trials that synovial sarcoma patients may be eligible for.

The hope is that these T cells will kill the cancer cells. Another study, which is open to patients with various types of sarcoma, is trying to determine if we can successfully treat sarcoma by combining checkpoint inhibitors MEDI and tremelimumab.

Synovial sarcoma can be inactive for a long time before it grows again to a size that can be detected by a scan. My Chart.

Chronic venous insufficiency that develops as a result of DVT is also known as post-thrombotic syndrome. As many as 30 percent of people with DVT will develop this problem within 10 years after diagnosis.

It occurs more frequently in people over age 50, and more often in women than in men. The seriousness of CVI, along with the complexities of treatment, increase as the disease progresses.

The problem will not go away if you wait, and the earlier it is diagnosed and treated, the better your chances of preventing serious complications.

Symptoms include:. If CVI is not treated, the pressure and swelling increase until the tiniest blood vessels in the legs capillaries burst. When this happens, the overlying skin takes on a reddish-brown color and is very sensitive to being broken if bumped or scratched.

At the least, burst capillaries can cause local tissue inflammation and internal tissue damage. At worst, this leads to ulcers, open sores on the skin surface.

These venous stasis ulcers can be difficult to heal and can become infected. When the infection is not controlled, it can spread to surrounding tissue, a condition known as cellulitis.

CVI is often associated with varicose veins, which are twisted, enlarged veins close to the surface of the skin. They can occur almost anywhere, but most commonly occur in the legs.

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To keep the blood flowing up, and not back down, the veins contain one-way valves. Chronic venous insufficiency occurs when these valves become damaged, allowing the blood to leak backward.

Valve damage may occur as the result of aging, extended sitting or standing or a combination of aging and reduced mobility.

When the veins and valves are weakened to the point where it is difficult for the blood to flow up to the heart, blood pressure in the veins stays elevated for long periods of time, leading to CVI.

CVI most commonly occurs as the result of a blood clot in the deep veins of the legs, a disease known as deep vein thrombosis DVT.

CVI also results from pelvic tumors and vascular malformations, and sometimes occurs for unknown reasons. Failure of the valves in leg veins to hold blood against gravity leads to sluggish movement of blood out of the veins, resulting in swollen legs.

Chronic venous insufficiency that develops as a result of DVT is also known as post-thrombotic syndrome. As many as 30 percent of people with DVT will develop this problem within 10 years after diagnosis.

It occurs more frequently in people over age 50, and more often in women than in men. The seriousness of CVI, along with the complexities of treatment, increase as the disease progresses.

The problem will not go away if you wait, and the earlier it is diagnosed and treated, the better your chances of preventing serious complications.

Symptoms include:. If CVI is not treated, the pressure and swelling increase until the tiniest blood vessels in the legs capillaries burst.

The lungs are the most common, and usually the first, site of metastasis for synovial sarcoma. Metastasis to the brain, bone, lymph nodes and local organs are all possibilities.

MD Anderson has two clinical trials that synovial sarcoma patients may be eligible for. The hope is that these T cells will kill the cancer cells. Another study, which is open to patients with various types of sarcoma, is trying to determine if we can successfully treat sarcoma by combining checkpoint inhibitors MEDI and tremelimumab.

Synovial sarcoma can be inactive for a long time before it grows again to a size that can be detected by a scan. My Chart. Donate Today.

For Physicians. Cancer Moonshots. Jump To:. August 23, Tell us about the types of synovial sarcoma and the differences between them.

Are certain patients more likely to develop synovial sarcoma than others? How is synovial sarcoma typically diagnosed?

How is synovial sarcoma typically treated? Is there a risk for metastasis and if so, where? Can you tell us about new synovial sarcoma clinical trials?

Is there anything else you want patients to know about synovial sarcoma? Read More by Devon Carter. Request an Appointment. Coronavirus Precautions.

Help EndCancer. Give Now. Your gift will help make a tremendous difference. Donate Blood. Learn more. Change the lives of cancer patients by giving your time and talent.

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